Fh-binding protein of streptococcus pneumoniae

Details Fh-binding protein of streptococcus pneumoniae Fh-binding protein of streptococcus pneumoniae

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/711 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/09 (2006.01) A61K 45/00 (2006.01) A61P 11/00 (2006.01) A61P 31/04 (2006.01) A61P 43/00 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2416657

The present invention provides proteins and peptides derived from Streptococcus pneumoniae, type 3, which bind the complement factor H (fH). These proteins and peptides show a homology of at least 50 %, preferably at least 60 %, and most preferably at least 70 % with the subsequence from Thr38 to Lys 149 of the sequence disclosed herein as SEQ ID NO:1. The above subsequence, which is located in the amino-terminal of a surface protein isolated from Streptococcus Pneumoniae, type 3, is highly associated with binding of fH. In another aspect, the invention relates to proteins and peptides showing a homology of at least 85 %, preferably at least 95 %, and most preferably at least 99 % with the Hic protein, the amino acid sequence of which is disclosed is SEQ ID NO:1. The invention also provides vaccine compositions comprising the above proteins and peptides.

Cette invention a trait à des protéines ainsi qu'à des peptides issus de Streptococcus pneumoniae, type 3, qui se fixent tous au facteur H de complément (fH). Ces protéines et ces peptides montrent une homologie d'au moins 50 %, de préférence d'au moins 60 % et, mieux encore, d'au moins 70 % avec la sous-séquence, allant de Thr 38 à Lys 49, de la séquence présentée dans le cadre de l'invention sous la référence SEQ ID N·:1. Cette sous-séquence, qui se trouve dans le N-terminal d'une protéine de surface isolée de Streptococcus pneumoniae, type 3, est largement associée à la fixation de fH. Un autre aspect de l'invention porte sur des protéines et des peptides montrant une homologie d'au moins 85 %, de préférence d'au moins 95 % et, mieux encore, d'au moins 99 % avec la protéine Hic, dont la séquence aminoacide est présentée dans le cadre de l'invention sous la référence SEQ ID N·:1. Cette invention concerne, de surcroît, des compositions vaccinales renfermant les protéines et peptides susmentionnés.

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