A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/095 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 14/22 (2006.01) C07K 17/02 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2695467
The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, using vesicle vaccines made from Neisseria strains have decreased or no detectable expression of a product of LpxL1 gene, and which optionally overexpress fHbp.
Cette invention concerne d'une manière générale des procédés et des compositions permettant de provoquer une réponse immunitaire dirigée contre la bactérie Neisseria spp. chez un sujet, en utilisant des vaccins vésiculaires fabriqués à partir de souches de Neisseria à expression réduite ou non détectable d'un produit de du gène LpxL1, et surexprimant éventuellement fHbp.
Granoff Dan
Hou Victor
Children's Hospital & Research Center At Oakland
Smart & Biggar
LandOfFree
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