Fiber-modified adenoviral vectors for enhanced transduction...

Details Fiber-modified adenoviral vectors for enhanced transduction... Fiber-modified adenoviral vectors for enhanced transduction...

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01) A01N 63/00 (2006.01) A61K 39/12 (2006.01) C12N 15/00 (2006.01) C12N 15/64 (2006.01) C12N 15/83 (2006.01)

Patent

CA 2577470

Adenoviral vectors which effectively transduce primary tumor cells are provided. The adenoviral vectors comprise a chimeric adenovirus fiber protein which includes at least a portion of a Subgroup C adenovirus fiber shaft and at least a portion of a Subgroup B adenovirus or serotype 37 adenovirus head, wherein the head region binds CD46.

L'invention concerne des vecteurs adénoviraux permettant une transduction efficace des cellules tumorales primaires. Lesdits vecteurs adénoviraux comprennent une protéine fibreuse d'adénovirus chimérique contenant au moins une partie du corps fibreux d'un adénovirus du sous-groupe C et au moins une partie de la tête d'un adénovirus du sous-groupe B ou d'un adénovirus de sérotype 37, la zone de la tête étant liée à CD46.

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