C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/34 (2006.01) C07K 14/075 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2474763
Provided are adenoviral vectors and the production of such vectors. In particular, fiber shaft modifications for efficient targeting of adenoviral vectors are provided. The fiber shaft modifications can be combined with other modifications, such as fiber knob and/or penton modifications, to produce fully ablated (detargeted) adenoviral vectors. A scale-up method for the propagation of detargeted adenoviral vectors is also provided.
L'invention concerne des vecteurs adénoviraux et leur production et, en particulier, des modifications de tige fibre pour un ciblage efficace de vecteurs adénoviraux. Les modifications de tige fibre peuvent être combinées à d'autres modifications, telles que des modifications de bouton fibre et/ou de penton, pour produire des vecteurs adénoviraux complètement ablatés (déciblés). La présente invention porte également sur un procédé de mise à l'échelle pour la propagation de vecteurs adénoviraux déciblés.
Kaleko Michael
Nemerow Glen R.
Smith Theodore
Stevenson Susan C.
Novartis Ag
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Scripps Research Institute
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