C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/39 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) C07K 1/113 (2006.01) C07K 7/06 (2006.01) C07K 14/315 (2006.01) C07K 14/78 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 11/02 (2006.01) C12N 15/57 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2083271
This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypep- tide having an amino acid sequence substantially present in the fibrin binding domain of naturally-occuring human fibronectin and being capable of binding to fibrin. The invention further provides a method wherein the imaging agent is used for imaging a fibrin-containing substance, i.e., a thrombus or atherosclerotic plaque. Further provided are plasmids for expression of polypep- tides having an amino acid sequence substantially present in the fibrin binding domain of naturally-occuring human fibronectin and being capable of binding to fibrin, hosts containing these plasmids, methods of producing the polypeptides, methods of treat- ment using the polypeptides, and methods of recovering, refolding and reoxidizing the polypeptides. The invention also provides for purified polypeptides substantially free of other substances of human origin which have an amino acid sequence substantially present in the fibrin binding domain of naturally-occuring human fibronectin and which are capable of binding to fibrin.
Guy Rachel
Hartman Jacob
Levanon Avigdor
Panet Amos
Shaked Hadassa
Bio-Technology General Corp.
Gowling Lafleur Henderson Llp
Savient Pharmaceuticals Inc.
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