C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 49/00 (2006.01) C07K 7/08 (2006.01) C07K 14/75 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2432474
The present invention provides binding moieties for fibrin which have a variety of uses wherever detecting, isolating or localizing fibrin, and particularly fibrin as opposed to fibrinogen, is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding fibrin and recognizing the form of polymerized fibrin found in thrombi. In addition, the polypeptides have a slow dissociation rate from fibrin, which improves their ability to form a contrast image at the site of a fibrin clot, making the disclosed binding moieties particularly useful as imaging agents for thrombi.
La présente invention concerne des fractions de fixation de la fibrine qui possèdent diverses utilisations, que ce soit dans la détection, dans l'isolation ou dans la localisation de la fibrine, et plus particulièrement la fibrine en tant qu'opposé au fibrinogène, est intéressante. Cette invention concerne particulièrement des polypeptides isolés synthétiques capables de se fixer à la fibrine et de reconnaître la forme de la fibrine polymérisée trouvée dans les thrombi. Par ailleurs, ces polypeptides possèdent une vitesse de dissociation des thrombi faible, ce qui améliore leur capacité de former une image de contraste au niveau d'un site de caillot de fibrine et rend ces fractions de fixation particulièrement utiles comme agents d'imagerie pour les thrombi.
Beltzer James P.
Sato Aaron K.
Wescott Charles R.
Dyax Corp.
Smart & Biggar
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