Fibrin coated polymer surfaces

Details Fibrin coated polymer surfaces Fibrin coated polymer surfaces

A - Human Necessities

61

L

A61L 33/00 (2006.01) A61L 27/00 (2006.01) A61L 27/34 (2006.01) A61L 33/12 (2006.01)

Patent

CA 2133974

Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and.prosthetic devices, and provide test systems useful in the study of thrombogenesis.

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