Fibrin d-domain multimer coated prostheses and methods for...

Details Fibrin d-domain multimer coated prostheses and methods for... Fibrin d-domain multimer coated prostheses and methods for...

A - Human Necessities

61

L

A61L 33/00 (2006.01) A61L 27/00 (2006.01)

Patent

CA 2176874

Methods for coating a prosthetic surface with anti-thrombogenic, or anti--coagulant, proteins are disclosed. The methods involve contacting a surface of a prosthetic material with a composition containing multimers of fibrin degradation products. The fibrin multimers, preferably D-dimers, have cross-linked D- domains. The methods of the invention are useful for providing an anti-thrombogenic coating on prosthetic implants which are exposed to a patient's blood after implantation, for example vascular grafts and artificial heart valves.

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