Fibrin microbeads and uses thereof

Details Fibrin microbeads and uses thereof Fibrin microbeads and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 11/08 (2006.01) A61K 9/127 (2006.01) A61K 9/16 (2006.01) A61K 9/22 (2006.01) A61K 9/26 (2006.01) A61K 9/50 (2006.01) A61L 26/00 (2006.01) A61L 27/22 (2006.01) A61L 27/38 (2006.01) C07K 14/75 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 9/48 (2006.01) A61F 2/00 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2304384

The present invention provides fibrin microbeads that are biologically active and comprise extensively cross-linked fibrin(ogen), and a method for preparing the fibrin microbeads. The present invention also provides a composition comprising cells bound to the fibrin microbeads, and methods for culturing and separating cells using the fibrin microbeads of the present invention. Finally, the present invention provides methods for transplanting cells and engineering tissue using the fibrin microbeads of the present invention.

L'invention concerne des microbilles de fibrine biologiquement actives à base de fibrine (fibrinogène) dont la réticulation est étendue. L'invention concerne aussi un procédé relatif à l'élaboration desdites microbilles. L'invention concerne en outre une composition renfermant des cellules liées aux microbilles en question, ainsi que des procédés permettant la culture et la séparation des cellules au moyen de ces microbilles. Enfin, l'invention concerne des procédés permettant la transplantation de cellules et les opérations de génie tissulaire, au moyen des microbilles considérées.

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