C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/75 (2006.01) A61K 38/36 (2006.01) A61K 47/48 (2006.01) C07K 14/745 (2006.01) C12N 5/00 (2006.01) C12N 11/02 (2006.01) C12P 21/06 (2006.01) C12Q 1/24 (2006.01)
Patent
CA 2458850
The present invention provides fibrin nanoparticles having a mean diameter of 200-2000 nm. The present invention provides also methods for preparing fibrin particles of various sizes, including fibrin nanoparticles and fibrin microbeads. The present invention further provides compositions comprising fibrin particles and an agent, wherein the agent is coupled to the amine or carboxy moieties on the surface of the fibrin particles. In addition the present invention provides a composition comprising fibrin nanoparticles and an agent, wherein the agent is admixed with the fibrin nanoparticles. Still further, the present invention provides a method for introducing an agent into a cell, a method for isolating stem and/or progenitor cells from a biological sample, as well as a composition comprising fibrin particles bound to stem and/or progenitor cells.
L'invention concerne des nanoparticules de fibrine présentant un diamètre moyen de 200 à 2000 nanomètres. L'invention concerne également des procédés permettant de préparer des particules de fibrine de tailles variées, y compris des nanoparticules de fibrine et des microbilles de fibrine. L'invention concerne également des compositions comprenant des particules de fibrine et un agent, dans lesquelles l'agent est relié à la fraction amine ou carboxy située à la surface des particules de fibrine. En outre, l'invention concerne une composition comprenant des nanoparticules de fibrine et un agent, dans laquelle l'agent est mélangé auxdites nanoparticules de fibrine. L'invention concerne encore un procédé permettant d'introduire un agent dans une cellule, un procédé permettant d'isoler des cellules souches et/ou des cellules primordiales, à partir d'un échantillon biologique, ainsi qu'une composition comprenant des particules de fibrine reliées à des cellules souches et/ou à des cellules primordiales.
Gorodetsky Raphael
Marx Gerard
Hapto Biotech Inc.
Osler Hoskin & Harcourt Llp
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