Fibrin sealants or adhesives comprising a hyaluronic acid...

A - Human Necessities – 61 – L

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A61L 24/10 (2006.01) A61K 9/00 (2006.01) A61K 38/36 (2006.01) A61L 24/04 (2006.01) A61L 24/08 (2006.01)

Patent

CA 2308462

An especially useful fibrin glue composition comprises a biocompatible, bioabsorbable hyaluronic acid derivative material, upon which are applied or chemically bonded fibrinogen and thrombin, along with other optional constituents, such as additional coagulation factors, anti-fibrinolytics, stabilizers and biologically active substances. The fibrinogen, thrombin and other components can take the form of a dry preparation, an aqueous or nonaqueous preparation, or as a combination thereof. Such a fibrin glue composition can be placed directly on a wound site and is fully reabsorbed into the body.

L'invention concerne une composition de colle de fibrine particulièrement utile comprenant un matériau dérivé d'acide hyaluronique, biocompatible, bio-absorbable sur lequel sont appliqués ou liés chimiquement du fibrinogène et de la thrombine, ainsi que d'autres constituants optionnels tels que des facteur de coagulation additionnels, des anti-fibrinolytiques, des stabilisateurs et des substances biologiquement actives. Le fibrinogène, la thrombine et les autres composants peuvent être présentés sous forme d'une préparation sèche, d'une préparation aqueuse ou non aqueuse ou d'une combinaison de ces dernières. Une telle composition de colle de fibrine peut être placée directement sur le site d'une plaie et est entièrement réabsorbée dans l'organisme.

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