Fibrin-specific and fibrinogen-specific monoclonal...

Details Fibrin-specific and fibrinogen-specific monoclonal... Fibrin-specific and fibrinogen-specific monoclonal...

C - Chemistry, Metallurgy

12

N

167/139, 167/37,

C12N 5/18 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/18 (2006.01) C07K 16/36 (2006.01) G01N 33/531 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339737

The subject invention provides fibrin-specific and fibrinogen-specific monoclonal antibodies that recognize novel epitopes: the monoclonal antibodies of the subject invention do not bind to plasmin derived fibrin or fibrinogen degradation products; the fibrinogen-specific monoclonal antibody does not inhibit the conversion of fibrinogen to fibrin; and the fibrin-specific monoclonal antibody does not bind to fibrin monomer. The subject invention further provides methods of obtaining such monoclonal antibodies by use of germ-free mice.

602660

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