A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 24/10 (2006.01) A61L 24/04 (2006.01)
Patent
CA 2349000
The present invention relates to a fibrin tissue ad-hesive formulation containing thrombin, fibrinogen and factor XIII, wherein the thrombin and fibrinogen with factor XIII is present as a mixture in pourable solid granule form and the granules have a particle size or 20-1000 µm. The granules can have a multi--layered set-up consisting of a core of sugar, a fi-brinogen layer and an outer layer of thrombin.
L'invention concerne une formulation d'adhésif tissulaire à base de fibrine, qui contient de la thrombine, du fibrinogène et du facteur XIII. La thrombine et le fibrinogène sont mélangés au facteur XIII de façon à se présenter sous forme de granulat solide à écoulement libre, ayant une granulométrie comprise entre 20 et 1000 mu m. Le granulat peut également être formé de plusieurs couches, avec un noyau constitué de sucres, une couche de fibrinogène et une couche externe de thrombine.
Luy Bernhard
Prasch Armin
Rapp Mirna
Csl Behring Gmbh
Glatt Process Technology Gmbh
Mcfadden Fincham
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