Fibrinogen binding moieties

Details Fibrinogen binding moieties Fibrinogen binding moieties

C - Chemistry, Metallurgy

07

K

C07K 14/75 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 17/00 (2006.01) G01N 33/53 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2479750

Compositions comprising non-naturally occurring fibrinogen binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating fibrinogen molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to fibrinogen. Preferred binding peptides having a high affinity for fibrinogen are particularly disclosed.

L'invention porte sur des compositions comprenant des fragments élaborés se fixant au fibrinogène, et sur leurs méthodes d'utilisation par exemple pour détecter ou isoler des molécules de fibrinogène présente dans une solution, pour représenter la circulation sanguine, et pour fixer des substances thérapeutiques ou d'autres molécules au fibrinogène. L'invention présente en particulier des peptides préférés ayant une forte affinité pour le fibrinogène.

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