Fibrinogen-free plasminogen-plasmin-free plasma and method...

Details Fibrinogen-free plasminogen-plasmin-free plasma and method... Fibrinogen-free plasminogen-plasmin-free plasma and method...

A - Human Necessities

61

K

167/114

A61K 35/16 (2006.01)

Patent

CA 1068601

FIBRINOGEN-FREE PLASMINOGEN-PLASMIN-FREE PLASMA AND METHOD OF PREPARING AND USING SAME ABSTRACT OF THE DISCLOSURE: A method of treating blood plasma or fractionated plasma products with fumed colloidal silica to remove fibrinogen with- out polymerization to fibrin, to remove the plasminogen-plasmin proteolytic enzyme system, to remove cholesterol and lipoproteins and reduce triglycerides, while maintaining plasma coagulation factor II at pretreatment levels and leaving immunoglobulins and other protein constituents unaffected, and the resulting product. Plasma products treated with fumed silica may be subjected to long-term storage for a year or more without loss of its bio- logically active support properties, thereby circumventing the problem of hepatitis. The treated plasma products, either fresh or after long-term storage, may be used as a perfusion support media for organ perfusion, for treatment of hemorrhagic shock and similar purposes for which untreated plasma and fractionated plasma products are customarily used, with equal or superior effectiveness.

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