Fibrinogen receptor antagonists

Details Fibrinogen receptor antagonists Fibrinogen receptor antagonists

C - Chemistry, Metallurgy

07

K

530/7.06, 167/10

C07K 7/06 (2006.01) A61K 38/08 (2006.01)

Patent

CA 2021949

7652P/ 7/28/89: Fl 17986 TITLE OF THE INVENTION LINEAR FIBRINOGEN RECEPTOR ANTAGONISTS ABSTRACT OF THE DISCLOSURE A fibrinogen receptor antagonist compound of the structure: A-B-C-Gly-Asp-D-E (I) wherein A, B, C, D and E are preferably ffollows: A is L-asparagine, D-asparagine or acylated asparagine B is an L-or D-isoer of proline, thioproline, .beta.,.beta.-dimethylthioproline, or N-methylalanine; C is arginine; D is phenylalanine, tryptophan .alpha.-naphthylalanine, .beta.-napthlalanine, arginine or lysine; and E is OH.

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