Fibrinolytic protein and production method thereof

Details Fibrinolytic protein and production method thereof Fibrinolytic protein and production method thereof

C - Chemistry, Metallurgy

12

N

530/13, 195/39,

C12N 9/54 (2006.01) A61K 38/48 (2006.01) C12N 9/50 (2006.01)

Patent

CA 2030927

Abstract: A novel peptide having molecular weight of 31,000 is obtained from aqueous extract of Natto or the culture of Bacillus natto by purification procedures including alcohol fractionation and/or salting out and hydrophobic chromatograsphy, and the physicochemical properties, including the amino acid sequence, of the peptide are determined. The peptide is active in fibrinolysis, exhibits strong thrombolytic activity by oral administration and is useful as an oral thrombolytic agent.

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