C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 5/02 (2006.01) A61K 31/69 (2006.01) A61P 35/00 (2006.01) C12N 9/99 (2006.01) A61K 38/05 (2006.01) C07D 207/10 (2006.01) C07K 5/06 (2006.01) C12N 9/64 (2006.01)
Patent
CA 2606785
Amino terminus-blocked peptide boronate compounds of Formulas (I) and (II) are useful for inhibiting Fibroblast Activation Protein (FAP) and other proteases, and for treating disorders mediated by FAP. Methods of using the amino terminus blocked peptide boronate compounds, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
La présente invention a trait à des composés de boronate de peptide à blocage de terminaison amino de formules (I) et (II) utiles pour l'inhibition de la protéine d'activation de fibroblastes et d'autres protéases, et pour le traitement de troubles médiés par la protéine d'activation de fibroblastes. L'invention a également trait à des procédés d'utilisation des composés de boronate de peptide à blocage de terminaison amino, et de stéréoisomères, tautomères, solvates et de sels pharmaceutiquement acceptables de ceux-ci, pour le diagnostic, in vitro, in situ, etin vivo, la prévention ou le traitement de tels troubles dans des cellules mammaliennes, ou de conditions pathologiques associées.
Cohen Frederick
Fairbrother Wayne J.
Quan Clifford
Sutherlin Daniel P.
Wolf Beni B.
Genentech Inc.
Smart & Biggar
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