Fibroblast growth factor-13

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/19 (2006.01) A01K 67/027 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 14/50 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) G01N 33/68 (2006.01) G01N 33/88 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2272239

The present invention relates to a FGF-13 protein which is a member of the fibroblast growth factor (FGF) family. In particular, isolated nucleic acid molecules are provided encoding the human FGF-13 protein. FGF-13 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FGF-13 activity. Also provided are diagnostic methods for detecting FGF-13-related disorders and therapeutic methods for treating FGF-13-related disorders. Disclosed is a method of prolonging dopaminergic neuron survival.

La présente invention concerne une protéine du FGF-13, laquelle est un membre de la famille des facteurs de croissance des fibroblastes. On décrit notamment des molécules d'acide nucléique isolées, codant la protéine humaine du FGF-13, ainsi que des polypeptides du FGF-13 en tant que vecteurs et cellules hôtes, de même que des procédés de recombinaison destinés à la production de ces vecteurs et cellules hôtes. L'invention concerne encore des procédés de criblage destinés à identifier des agonistes et des antagonistes de l'activité du FGF-13, des techniques de diagnostic servant à détecter des troubles se rapportant au FGF-13, ainsi que des procédés thérapeutiques destinés au traitement des troubles associés au FGF-13. L'invention concerne enfin un procédé destiné à prolonger la survie des neurones dopaminergiques.

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