Fibroblast growth factor antagonists

Details Fibroblast growth factor antagonists Fibroblast growth factor antagonists

C - Chemistry, Metallurgy

12

N

530/7.1, 195/1.3

C12N 15/18 (2006.01) C07K 14/50 (2006.01)

Patent

CA 1340976

Antagonists to basic fibroblast growth factor, a 146 amino acid residue polypeptide, are produced. These antagonists are generally between 10 and 41 residues in length and are characterized by their ability to interact with the FGF receptor and/or inhibit and therefore modulate endothelial and other cell growth. These antagonists include the sequence of bovine basic FGF(106-115;1, namely Tyr-Arg-Ser-Arg-Lys- Tyr-Ser-Ser-Trp-Tyr; however, there may be one or more substitutions made in such sequence to create biologically potent analogs thereof. These peptides are also antagonistic to acidic FGF and other members of the family of FGF peptides. They are effective to combat FGF-promoted mitosis in melanomas and the like.

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