A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01)
Patent
CA 2542638
The present invention is directed to an antibody or fragments thereof that are specific for a fibroblast growth factor receptor (FGFR)-1(IIIb), FGFR-1(IIIc), and/or FGFR-4. Also, provided herein, are vectors and host cells comprising the nucleic acids encoding those antibodies. The present invention further provides methods of antagonizing FGFR-1 or FGFR-4 as a treatment for obesity, diabetes, or a condition related thereto, and methods of reducing food intake.
L'invention concerne un anticorps ou des fragments d'anticorps spécifiques du récepteur du facteur de croissance du fibroblaste (FGFR)-1(IIIb), FGFR-1(IIIc) et/ou FGFR-4. L'invention concerne également des vecteurs et des cellules hôtes contenant les acides nucléiques codant ces anticorps. L'invention concerne encore des méthodes destinées à antagoniser FGFR-1 ou FGFR-4, utilisées dans le traitement de l'obésité, du diabète ou d'un état associé, ainsi que des méthodes visant à réduire la prise alimentaire.
Shen Juqun
Sun Haijun
Tonra James R.
Gowling Lafleur Henderson Llp
Imclone Llc
Imclone Systems Incorporated
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