Fibroblast growth factor with hepatocyte proliferation activity

Details Fibroblast growth factor with hepatocyte proliferation activity Fibroblast growth factor with hepatocyte proliferation activity

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/50 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2305682

An additional member of the fibroblast growth factor (FGF) family of polypeptides has now been discovered and purified which has been found to exert a hepatocyte-specific mitogenic activity that distinguishes it from other FGF members. DNA molecules encoding this polypeptide can be used in gene therapy modes of administration to stimulate the proliferation of hepatocytes in vivo, or alternatively, they can be utilized in recombinant methods to produce the polypeptide for cell culture use or for therapeutic use to treat liver conditions requiring the generation and growth of hepatocytes.

On a découvert un nouveau polypeptide s'ajoutant aux membres de la famille des facteurs de croissance des fibroblastes (FGF), et on l'a purifié, de sorte qu'on a pu observer qu'il exerce une action mitogénique spécifique selon les hépatocytes, qui le distingue des autres membres de la famille FGF. Des molécules d'ADN codant ce polypeptide peuvent être utilisées dans des modes d'administration de thérapie génique pour stimuler la prolifération des hépatocytes in vivo, ou, dans une variante, ces molécules peuvent servir dans des procédés de recombinaison pour produire ce polypeptide en vue de la culture de cellules ou en vue d'une utilisation thérapeutique pour traiter des états hépatiques nécessitant la production et la croissance d'hépatocytes.

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