Fibronectin peptides-based extracellular matrix for wound...

Details Fibronectin peptides-based extracellular matrix for wound... Fibronectin peptides-based extracellular matrix for wound...

A - Human Necessities

61

K

A61K 38/39 (2006.01) A61K 38/00 (2006.01) A61P 17/02 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2321933

The invention provides an extracellular matrix for wound healing comprising peptides from two or more fibronectin domains in a backbone matrix. In one embodiment, the subject invention provides a hyaluronic acid backbone derivatized with the minimal FN sequences that are optimal for tissue cell recruitment. These constructs can be used to accelerate the healing of acute gaping cutaneous wounds and chronic cutaneous ulcers. The invention thus further provides a method of enhancing wound healing which comprises applying the extracellular matrix to a wound.

L'invention porte sur une matrice extracellulaire destinée à la cicatrisation des blessures et comprenant des peptides provenant d'au moins deux domaines de fibronectine dans une matrice de squelette. Selon une réalisation, l'invention permet de produire un squelette d'acide hyaluronique dérivé des séquences minimales de fibronectine qui sont optimales pour le recrutement des cellules tissulaires. Ces produits de recombinaison peuvent être utilisés pour accélérer la cicatrisation des plaies cutanées béantes et des ulcères cutanés chroniques. L'invention porte également sur un procédé d'accélération de la cicatrisation des blessures qui consiste à appliquer la matrice extracellulaire sur une blessure.

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