C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/78 (2006.01) A61K 38/39 (2006.01) A61L 27/32 (2006.01) C40B 40/10 (2006.01) C40B 50/00 (2006.01) C40B 50/06 (2006.01) G01N 33/68 (2006.01) C12N 15/00 (2006.01) C12N 15/12 (2006.01) C40B 30/04 (2006.01)
Patent
CA 2741834
A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
La présente invention concerne un échafaudage protéique basé sur une séquence consensus de protéines fibronectines de type III (FN3) de la fibronectine humaine (ténascine humaine), qui comprend des acides nucléiques isolés qui codent pour un échafaudage protéique, des vecteurs, des cellules hôtes, et des procédés de fabrication et d'utilisation associés ayant des applications dans des compositions diagnostiques et/ou thérapeutiques, des procédés et des dispositifs. Notamment, des molécules d'échafaudage protéique se liant aux IgG ont été identifiées comme étant utiles pour des applications diagnostiques et/ou thérapeutiques.
Jacobs Steven
O'neil Karyn
Centocor Ortho Biotech Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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