Fibrosis susceptibility gene and uses thereof

Details Fibrosis susceptibility gene and uses thereof Fibrosis susceptibility gene and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2752802

The present invention discloses the identification of a fibrosis susceptibility gene locus, the CTGF gene locus, which can be used for detecting predisposition to, diagnosis and prognosis of fibrosis as well as for the screening of therapeutical-ly active drugs. The invention resides, in particular, in a method which comprises detecting in a sample from the subject the pres-ence of an alteration in the CTGF gene locus, the presence of said alteration being indicative of the presence or predisposition to fibrosis.

Cette invention concerne l'identification d'un locus du gène de sensibilité à la fibrose, le locus du gène CTGF, qui peut être utilisé pour dépister une prédisposition à la fibrose, diagnostiquer et pronostiquer la fibrose ainsi que pour identifier par criblage des principes thérapeutiquement actifs. L'invention réside, en particulier, en un procédé qui comprend la détection dans un échantillon provenant du sujet d'une altération du locus du gène CTGF, la présence de ladite altération étant indicatrice de la présence ou d'une prédisposition à la fibrose.

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