C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 1/22 (2006.01) C07K 14/705 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2064818
2064818 9102755 PCTABS00003 The invention is directed to a substantially purified protein, hereinafter termed ''Fibulin'', that interacts with the cytoplasmic domain of the .beta. subunits shared by the fibronectin receptor and some other integrins. This invention is further directed to isolates of nucleic acid encoding Fibulin and to expression vectors harboring such nucleic acid in expressible form, to microorganism strains or cell cultures transformed with them and to recombinantly produced Fibulin obtainable via expression of DNA encoding Fibulin in a transfected recombinant host system. Still further the invention is directed towards antibodies reactive with Fibulin, be they monoclonal or polyclonal, and to nucleotide sequences capable of specifically hybridizing with nucleic acids encoding Fibulin.
Argraves W. Scott
Ruoslahti Erkki I.
American National Red Cross
Argraves W. Scott
Gowling Lafleur Henderson Llp
La Jolla Cancer Research Foundation
Ruoslahti Erkki I.
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