Filamentous bacteriophage displaying protein as a binder of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61P 3/06 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2642473

The present invention relates to a phage display vehicle composed of a filamentous bacteriophage displaying on its surface, as a non-filamentous bacteriophage molecule, protein A or a fragment or variant thereof capable of binding the Fc portion of antibodies, and an antibody or an antigen-antibody immunocomplex bound to protein A or a fragment or variant thereof by its Fc portion. The phage display vehicle is formulated into a pharmaceutical composition and can be used to treat/inhibit or to diagnose a brain disease, disorder or condition.

La présente invention concerne un véhicule de présentation phagique constitué d'un bactériophage filamenteux présentant sur sa surface, comme molécule bactériophagique non filamenteuse, une protéine A ou un fragment ou un variant de celle-ci, capable de se lier à la partie Fc d'anticorps, ainsi qu'un anticorps ou un immunocomplexe antigène-anticorps lié à la protéine A ou à un fragment ou un variant de celle-ci par l'intermédiaire de sa partie Fc. Le véhicule de présentation phagique est préparé en composition pharmaceutique et peut être utilisé pour traiter/inhiber ou diagnostiquer une maladie, un trouble ou une affection cérébral(e).

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