Filamentous fungi with impaired ptrb activity for altered...

Details Filamentous fungi with impaired ptrb activity for altered... Filamentous fungi with impaired ptrb activity for altered...

C - Chemistry, Metallurgy

12

N

C12N 1/15 (2006.01) C12N 1/14 (2006.01) C12N 15/00 (2006.01) C12N 15/80 (2006.01) C12P 21/02 (2006.01) C07K 14/37 (2006.01) C07K 14/38 (2006.01)

Patent

CA 2743634

A filamentous fungal cell is provided comprising at least one mutation, wherein the filamentous fungal cell has impaired ptrB activity and has altered expression of a protein of interest as compared to a corresponding parent filamentous fungal cell. In one embodiment, the altered expression of the protein of interest is enhanced expression of the protein of interest.

La présente invention concerne une cellule de champignon filamenteux comprenant au moins une mutation, ladite cellule présentant une activité ptrB défaillante et comportant une expression modifiée dune protéine dintérêt par rapport à une cellule de champignon filamenteux parente correspondante. Dans un mode de réalisation, lexpression modifiée de la protéine dintérêt est une expression améliorée de la protéine dintérêt.

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