C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/15 (2006.01) C07K 14/38 (2006.01) C12N 15/52 (2006.01) C12N 15/80 (2006.01)
Patent
CA 2720827
The invention relates to a filamentous fungal cell (e.g., Aspergillus sp.) comprising at least one inactivated protease gene chosen from apsB, a homolog of apsB, cpsA, a homolog cpsA, and combinations thereof. Nucleic acids and methods for making the inactivated mutant filamentous fungal cells are provided as well as methods for using the cells for the altered production of endogenous or heterologous proteins of interest.
Cette invention concerne une cellule fongique filamenteuse (par exemple, Aspergillus sp.) comprenant au moins un gène de la protéase inactivé, ledit gène étant choisi parmi apsB, un homologue d'apsB, cpsA, un homologue de cpsA, et leurs combinaisons. Des acides nucléiques et des procédés pour préparer les cellules fongiques filamenteuses mutantes inactivées sont décrits ainsi que des procédés d'utilisation desdites cellules pour modifier la production des protéines endogènes ou hétérologues d'intérêt.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Danisco Us Inc.
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