Filler composition for soft tissue augmentation and...

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/20 (2006.01) A61L 24/08 (2006.01) A61L 26/00 (2006.01) A61L 27/24 (2006.01) A61L 27/50 (2006.01) A61L 27/52 (2006.01)

Patent

CA 2429165

The present invention relates to a filler composition for soft-tissue augmentation and reconstructive surgery comprising an effective amount of an injectable thermo-gelling solution comprising 0.1 to 5.0 % by weight of chitosan or collagen or a derivative thereof; and 1.0 to 20 % by weight of a salt of polyol or sugar selected from the group consisting of mono-phosphate dibasic salt, mono-sulfate salt and a mono-carboxylic acid salt of polyol or sugar. The solution is stable and turns into a gel within a tem-perature range from 20 to 70 ~C. The gel has a cosmetically acceptable consistency for providing a mechanical support to surrounding soft tissues once injected therein. The composition can thus be used as filler for soft tissue augmentation and reconstructive surgery.

La présente invention concerne une composition de remplissage permettant l'augmentation de volume des tissus mous et la chirurgie reconstructive, comprenant une quantité efficace d'une solution thermo-gélifiante injectable comprenant 0,1 à 0,5 % en poids de chitosane ou collagène ou d'un dérivé correspondant; et 1,0 à 20 % en poids d'un sel de polyol ou sucre choisi parmi le groupe comprenant le sel dibasique de monophosphate, le sel de monosulfate et un sel d'acide monocarboxylique de polyol ou de sucre. La solution est stable et se gélifie à une température allant de 20 à 70 ·C. le gel a une consistance acceptable du point de vue cosmétique et peut servir de support mécanique aux tissus mous périphériques une fois injecté à l'intérieur de ceux-ci. La composition peut ainsi être utilisé en tant qu'agent de remplissage permettant l'augmentation de volume des tissus mous et la chirurgie reconstructive.

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