Film-coated and/or granulated calcium-containing compounds...

Details Film-coated and/or granulated calcium-containing compounds... Film-coated and/or granulated calcium-containing compounds...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A23L 1/09 (2006.01) A23L 1/303 (2006.01) A23L 1/304 (2006.01) A61K 9/20 (2006.01) A61K 33/06 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2631827

Calcium-containing compounds have been at least partly film-coated and/or granulated with a water-soluble substance and a water-soluble polymeric substance and use of such coated compounds in pharmaceutical compositions. The at least partly film-coated and/or granulated calcium-containing compounds have proved suitable for the preparation of tablets having a very high load of elemental calcium and a conveniently small size. A drug load of about 96% or more is obtained in tablets of the invention that have sufficient mechanical and organoleptic properties.

La présente invention concerne des composés contenant du calcium qui ont été au moins partiellement pelliculés et/ou granulés avec une substance soluble dans l'eau et une substance polymère soluble dans l'eau et l'utilisation de tels composés enrobés dans des compositions pharmaceutiques. Les composés contenant du calcium au moins partiellement pelliculés et/ou granulés se sont avérés adaptés pour la préparation de comprimés ayant une charge très élevée de calcium élémentaire et une petite taille qui leur confère un côté pratique. Une charge de médicament d'environ 96 % ou plus est obtenue dans des comprimés de l'invention qui ont des propriétés mécaniques et organoleptiques suffisantes.

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