Film coated tablet comprising an extract of red vine leaves

Details Film coated tablet comprising an extract of red vine leaves Film coated tablet comprising an extract of red vine leaves

A - Human Necessities

61

K

A61K 9/28 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2512149

The invention relates to a film coated tablet comprising the following constituents: a) at least 50 % by weight of a dried extract of red vine leaves, which is obtainable by extraction of red vine leaves with water and drying; b) up to 50 % by weight of an excipient consisting essentially of at least one binder, at least one disintegrant, at least one filler, and a lubricant; and c) a tablet film consisting essentially of a film former, a plastiziser, a coating agent and optionally a coloring agent.Furthermore, the invention relates to an aqueous extract of red vine leaves is obtainable by a method comprising the steps of: a) collecting red vine leaves at a point of time when the content in flavonoids has reached an optimum; b) drying and crushing the leaves; c) cutting the leaves to pieces; d) extracting the leaves with water at elevated temperatures for 6 to 10 hours; e) concentrating and drying the obtained extract, andaddition of up to 10 % by weight of a flow regulator during the relating to the final total amount of the resulting extract during the drying process (e).

L'invention concerne un comprimé enrobé par un film comprenant les composants suivants: (a) au moins 50 % en poids d'un extrait séché de feuilles de vigne rouges, pouvant être obtenu par extraction des feuilles de vigne rouges, à l'aide d'eau, et par séchage; (b) jusqu'à 50 % en poids d'un excipient comprenant principalement au moins un liant, au moins un délitant, au moins un agent de remplissage et un lubrifiant; et (c) un film de comprimé comprenant principalement un agent filmogène, un plastifiant, un agent d'enrobage et éventuellement un colorant. L'invention concerne en outre un extrait aqueux de feuilles de vigne rouges pouvant être obtenu au moyen d'un procédé qui comprend les étapes consistant: (a) à recueillir des feuilles de vigne rouges au moment où la teneur en flavonoïdes a atteint un point optimum; (b) à sécher et à broyer les feuilles; (c) à couper les feuilles en morceaux; (d) à extraire les feuilles, à l'aide d'eau, à des températures élevées pendant 6 à 10 heures; (e) à concentrer et à sécher l'extrait obtenu, et à ajouter jusqu'à 10 % en poids d'un régulateur d'écoulement associé à la teneur totale finale de l'extrait obtenu pendant l'étape (e) de séchage.

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