Film-coated tablet for improved upper gastrointestinal tract...

Details Film-coated tablet for improved upper gastrointestinal tract... Film-coated tablet for improved upper gastrointestinal tract...

A - Human Necessities

61

K

A61K 9/28 (2006.01) A61K 31/138 (2006.01) A61K 31/375 (2006.01) A61K 31/401 (2006.01) A61K 31/49 (2006.01) A61K 31/522 (2006.01) A61K 31/65 (2006.01) A61K 31/675 (2006.01) A61K 45/00 (2006.01)

Patent

CA 2293815

A novel oral dosage to be delivered to the stomach comprising a safe and effective amount of an active ingredient selected from the group consisting of emepronium bromidebromide, doxycycline, and other tetracyclines/antibiotics, iron preparations, quinidine, nonsteroidal anti-inflammatory drugs, alprenolol, ascorbic acid, captopril, theophylline, zidovoudine (AZT), bisphosphonates and mixtures thereof and pharmaceutically acceptable excipients, wherein said oral dosage form is a generally oval form and film coated to facilitate rapid esophageal transit and avoid irritation in the mouth, buccal cavity, pharynx, and esophagus.

L'invention a trait à une nouvelle posologie à administration orale devant se libérer dans l'estomac comprenant des excipients acceptables du point de vue pharmaceutique ainsi qu'une quantité efficace et sans danger d'un ingrédient actif choisi dans le groupe constitué par l'emperonium bromure, la doxycyline, et par d'autres tétracyclines/antibiotiques, ainsi que par des préparations à base de fer, la quinidine, des anti-inflammatoires non stéroïdiens, l'alprénolol, l'acide ascorbique, le captopril, la théophylline, l'azidothymidine (AZT), des bisphosphonates et par leurs mélanges. Cette forme posologique, qui est généralement de forme ovale, est enrobée d'une pellicule afin de faciliter son transit dans l'oesophage et d'éviter d'irriter la bouche, la cavité buccale, le pharynx et l'oesophage.

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