Fimh adhesin-based vaccines

Details Fimh adhesin-based vaccines Fimh adhesin-based vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/108 (2006.01) A61K 39/40 (2006.01) C07K 14/245 (2006.01) C07K 16/12 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2379069

Purified polypeptides formed from amino acid sequences corresponding to domains derived from the adhesin protein, FimH, are disclosed. Also disclosed are compositions containing these novel polypeptides for use as vaccines and for generating specific antibodies for use in treatment and/or prevention of diseases, such as urinary tract infections, caused by bacteria of the family <i>enterobacteriaceae</i>, from which FimH is derived.

L'invention concerne des polypeptides purifiés constitués de séquences d'acides aminés correspondant à des domaines dérivés de la protéine adhésine appelée FimH. L'invention concerne également des compositions contenant ces polypeptides destinées à être utilisées comme vaccins et à générer des anticorps spécifiques destinés à être utilisés dans le traitement et/ou la prévention de maladies, telles que les infections urinaires, causées par des bactéries de la famille Entérobactériacées, de laquelle est dérivée FimH.

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