Fine-beaded colestipol hydrochloride

Details Fine-beaded colestipol hydrochloride Fine-beaded colestipol hydrochloride

C - Chemistry, Metallurgy

08

G

167/206, 402/278

C08G 73/02 (2006.01) A61K 31/785 (2006.01)

Patent

CA 1334467

The present invention provides for an improvement in the emul- sion copolymerization process for the preparation of fine-beaded colestipol hydrochloride (FBCH) wherein the improvement comprises: 1) utilizing a weight ratio of water to polyethylenepolyamine in the process of 1.8 to 3.6 grams per gram, and 2) utilizing a weight ratio of surface active agent or surfactant to polyethylenepolyamine in the process of 1.0 to 3.0 grams per kilogram; The colestipol hydrochloride product thus produced is a novel fine- beaded form of a known pharmaceutical composition, yielding pharmaceutically elegant dosage forms exhibiting increased potency, including non-gritty oral powders and oral tablets. Conventional colestipol hydrochloride was heretofore available in large spherical granules which produced less elegant (gritty) oral suspensions.

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