A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/20 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 31/075 (2006.01) A61K 45/00 (2006.01) A61K 47/26 (2006.01) A61K 47/30 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01) A61P 1/16 (2006.01)
Patent
CA 2751236
Disclosed are a composition containing a poorly soluble medicinal substance and having improved oral absorption, and a method for producing the composition. Specifically disclosed is a finely pulverized composition which contains a poorly soluble medicinal substance such as 22.beta.-methoxyolean-12-ene-3.beta.- ,24(4.beta.)-diol and a hydrophilic surfactant. Also specifically disclosed is a method for producing a finely pulverized composition, which is characterized in that a poorly soluble medicinal substance and a hydrophilic surfactant are first dispersed in a solvent, and then pulverized by a high-pressure homogenizer.
L'invention porte sur une composition contenant une substance médicinale médiocrement soluble et ayant une absorption orale améliorée et sur un procédé de production de la composition. L'invention porte spécifiquement sur une composition finement pulvérisée contenant une substance médicinale médiocrement soluble telle que le 22ß-méthoxyolean-12-ène-3ß-,24(4ß)-diol et un agent surfactant hydrophile. L'invention porte également spécifiquement sur un procédé de production d'une composition finement pulvérisée, caractérisé en ce qu'on dispose d'abord une substance médicinale médiocrement soluble et un agent surfactant hydrophile dans un solvant, puis qu'on les pulvérise à l'aide d'un homogénéisateur haute pression.
Chikase Shigeru
Kawada Dai
Fetherstonhaugh & Co.
Meiji Seika Pharma Co. Ltd.
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