Fish vaccine

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/18 (2006.01) A61K 39/12 (2006.01) C12N 5/10 (2006.01) C12N 15/40 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2622610

The present invention relates to veterinary immunology, namely to the immunological response of fish to a virus. More specifically, the invention provides an epitope of salmonid alphaviruses which epitope is capable of inducing a virus neutralising immune response. In particular the invention relates to a polypeptide comprising a certain amino acid sequence, a protein comprising such polypeptide, to a carrier comprising such protein, and to a method of producing antibodies. Further the invention relates to a nucleic acid encoding such polypeptide or such protein, and to a carrier comprising such a nucleic acid. Also, the invention relates to a vaccine and a diagnostic kit comprising such a polypeptide, protein, carrier, or nucleic acid.

La présente invention relève du domaine de l'immunologie vétérinaire, plus précisément de la réponse immunologique d'un poisson face à un virus. De manière plus spécifique, cette invention concerne un épitope d'alphavirus de salmonidés, lequel épitope est capable d'induire une réponse immune neutralisant le virus. Cette invention concerne en particulier un polypeptide comprenant une séquence donnée d'acide aminé, une protéine comprenant un tel polypeptide, un vecteur comprenant une telle protéine et un procédé de production d'anticorps. Cette invention concerne en outre un acide nucléique codant ce polypeptide ou cette protéine, ainsi qu'un vecteur comprenant cet acide nucléique. Cette invention concerne enfin un vaccin et une trousse de diagnostic comprenant ce polypeptide, cette protéine, ce vecteur ou cet acide nucléique.

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