C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/16 (2006.01) A61K 31/37 (2006.01) A61P 3/10 (2006.01) A61P 7/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 9/14 (2006.01) A61P 13/12 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2744828
This invention makes public that the five crystal forms of XLF-III-43 can be used as crude drugs, refers to the preparing methods of the five crystal forms of XLF- III-43 as crude drugs, refers to applying the sterling of the five crystal forms of XLF- III-43 and mixed crystals with different proportions as medicine active components to develop all kinds of medicines and compound medicines. In addition, this invention also refers to applying the crystal samples of XLF-III-43 as crude drugs to treat kidney dysfunction, cardiocerebral vessel diseases, hypertension, type II diabetic mellitus, complications of hypertension and diabetic mellitus, tumor, precancerosis, edema , and bring therapeutic effects by enhancing blood drug levels resulted from effects of crystal forms in the processes of treating all kinds of diseases.
La présente invention concerne les cinq formes cristallines du composé de nicousamide en tant que produits pharmaceutiques. Les procédés de préparation du produit pharmaceutique des cinq formes cristallines du composé de nicousamide. Tous les types de médicaments et les compositions pharmaceutiques préparés en utilisant les produits purifiés de ces cinq formes cristallines et leur cristaux mixtes avec une proportion quelconque en tant que substance active des matériaux pharmaceutiques. Les utilisations des échantillons de formes cristallines du nicousamide en tant que matériaux pharmaceutiques dans linsuffisance rénale, des maladies cardiovasculaires et cérébrovasculaires, lhypertension, le diabète de type II, une complication de lhypertension ou du diabète, une tumeur, une lésion précancéreuse et des hydrops. Les utilisations de laugmentation du taux sanguin de médicament in vivo et la production de leffet de traitement dans le processus de traitement de tous types de maladies par linfluence des formes cristallines.
Chen Xiaoguang
Lv Yang
Wang Cheng
Xie Ping
Zhang Li
Benoit & Cote Associes Inc.
Institute Of Mataria Medica Chinese Academy Of Medical Sciences
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