Five-helix protein

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/16 (2006.01) A61K 38/16 (2006.01) A61P 31/18 (2006.01) C07K 16/10 (2006.01) C12N 15/49 (2006.01) G01N 33/50 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2395291

Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six- Helix protein, which inlcudes the three N-helices and the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, is also disclosed.

La présente invention concerne une protéine à cinq hélices qui comporte trois hélices N et au moins deux, mais pas trois, des trois hélices C du trimère de la structure en épingle à cheveux de gp41 du VIH, séparées par des lieurs, tels que des lieurs de restes d'acides aminés. La protéine à six hélices qui comprend les trois hélices N et les trois hélices C du trimère de la structure en épingle à cheveux de gp41 du VIH, séparées par des lieurs est également présentée.

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