Five-membered ring compound

Details Five-membered ring compound Five-membered ring compound

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/501 (2006.01) A61K 31/5377 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/04 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/04 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2722007

Provided are a five-membered ring compound represented by formula (1) or a pharmaceutically acceptable salt thereof, and a medicine containing the compound or salt. The compound or salt inhibits the infiltration of leukocytes such as eosinophils and lymphocytes, is effective as a therapeutic agent for various kinds of inflammation, and is so safe that the compound or salt can be taken for long. (see formula 1) In formula (1), R1 is (substituted) phenyl or pyridyl, R2 is (substituted) pyrazinediyl, pyrimidinediyl, or pyridazinediyl, R3 to R5 each is alkyl (provided that -N(R4)R5 may be morpholino), and Y2 is alkylene.

L'invention concerne : un composé cyclique à cinq éléments représenté par la formule (1) ou un sel pharmacologiquement acceptable de celui-ci ; et un médicament contenant ledit composé ou sel. Le composé ou sel selon l'invention inhibe l'infiltration de leucocytes, tels que des éosinophiles, et de lymphocytes ; il est efficace en tant qu'agent thérapeutique pour divers types d'inflammation ; et peut être administré pendant de longues périodes du fait de son innocuité. Dans la formule (1), R1 représente phényle ou pyridyle (substitué) ; R2 représente pyrazinediyle, pyrimidinediyle ou pyridazinediyle (substitué) ; R3 à R5 représentent chacun alkyle (à condition que -N(R4)R5 soit morpholino) ; et Y2 représente alkylène.

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