Fixation devices for tissue repair

A - Human Necessities – 61 – L

Patent

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Details

A61L 31/04 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01) A61L 33/00 (2006.01)

Patent

CA 2449323

Fixation devices for tissue repair, for example sutures, surgical arrows, staples, darts, bolts, screws, buttons, anchors, nails, rivets or barbed devices comprise at least one of angiogenic material; angiogenic precursor material which is capable of breaking down in vivo to form angiogenic material; and tissue-engineered material, which tissue-engineered material is capable of producing angiogenic material. In a preferred form the material is incorporated into a polymer matrix having predetermined hydrophobicity to allow controlled release of angiogenic materials such as butyric or hydroxybutyric acid or salts thereof. Polymer matrix compositions comprising angiogenic materials and methods for tissue repair are also provided.

L'invention concerne des dispositifs de fixation pour la réparation de tissus, par exemple des sutures, des flèches, des agrafes, des flèches, des boulons, des vis, des boutons, des ancres, des clous, des rivets ou des dispositifs à barbes chirurgicaux comprenant au moins une matière angiogénique ; une matière de précurseur angiogénique capable de se décomposer <i>in vivo </i>pour former une matière angiogénique ; et une matière obtenue par génie tissulaire, laquelle matière obtenue par génie tissulaire est capable de produire une matière angiogénique. Dans une forme préférée, la matière est incorporée dans une matrice polymère ayant une hydrophobicité prédéterminée pour permettre la libération régulée de manière angiogénique telle que de l'acide butyrique ou hydroxybutyrique ou ses sels. L'invention concerne également des compositions de matrice polymère contenant des matières angiogéniques et des méthodes de réparation de tissus.

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