Fizz proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2326001

The present invention is directed to novel polypeptides, designated FIZZ, which are secreted low molecular weight molecules showing no significant sequence homology to any known protein, and nucleic acid sequences encoding such proteins. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptide of the present invention fused to heterologous polypeptide sequences, and antibodies which bind to the polypeptides of the present invention. Methods of using FIZZ polypeptides to treat various neurotrophin- related conditions are further provided.

La présente invention concerne de nouveaux polypeptides, désignés sous le nom de FIZZ, qui sont des molécules sécrétés de faible poids moléculaire ne présentant pas d'homologie de séquence particulière avec une quelconque protéine connue, ainsi que les séquences nucléotidiques codantes pour ces protéines. L'invention concerne également des vecteurs et des cellules hôtes comprenant des séquences nucléotidiques, des molécules polypeptidiques chimères comprenant le polypeptide de la présente invention fusionné à des séquences polypeptidiques hétérologues, et des anticorps liant les polypeptides de la présente invention. L'invention concerne enfin des méthodes d'utilisation des polypeptides FIZZ pour traiter divers états associés à la neutrophine.

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