Flavivirus ns1 subunit vaccine

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/40 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 39/12 (2006.01) A61K 39/20 (2006.01) A61P 31/12 (2006.01) A61P 31/14 (2006.01) C07K 14/18 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/863 (2006.01)

Patent

CA 2466413

The present invention relates to NS1 proteins or parts thereof of Flaviviruses, in particular of Dengue viruses useful for vaccination against said Flavivirus and against one or more other Flaviviruses. The invention further concerns the NS1 protein or parts thereof of one Dengue virus serotype, in particular serotype 2, useful for vaccination against Dengue viruses from all serotypes. The invention further concerns DNA comprising an expression cassette coding for a Flavivirus NS1 or parts thereof, vectors, comprising said DNA and vaccines containing or expressing a Flavivirus NS1.

La présente invention concerne des protéines NS1 ou des parties de celles-ci, de Flavivirus, en particulier de virus Dengue, utiles pour la vaccination contre lesdits Flavivirus et contre un ou plusieurs autres Flavivirus. L'invention a également pour objet la protéine NS1 ou des parties de celle-ci, d'un sérotype de virus Dengue, en particulier du sérotype 2, utiles pour la vaccination contre les virus Dengue de tous les sérotypes. L'invention concerne également de l'ADN comprenant une cassette d'expression codant pour une NS1 ou des parties de celle-ci de Flavivirus, des vecteurs comprenant ledit ADN, et des vaccins contenant ou exprimant une NS1 de Flavivirus.

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