C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/244, 260/354
C07D 407/12 (2006.01) A61K 31/35 (2006.01) C07D 407/04 (2006.01)
Patent
CA 1337124
The invention is concerned with novel pharmaceutically active silibinin derivatives having the general formula: Image wherein n and m, independently of one another, stand for 0 or 1, Alk1 and Alk2, independently of one another, are alkylene radicals containing up to 4 carbon atoms or alkenylene radicals containing 2 to 4 carbon atoms and M1 and M2, independently of each other, stand for hydrogen atoms or alkali metal atoms. The compounds according to the present invention are effective for the treatment of fungal poisonings, especially the very dangerous poisoning caused by the fungus known as green death cap or deadly ageric (Amanita phalloides). Poisonings by halogenated organic solvents, such as carbon tetrachloride, tri- chloroethylene, chloroform and the like, can also be surprisingly well treated therewith. In the case of a prophylactic use, the compounds according to the present invention prevent the above-described damage.
495804
Braatz Reinhard
Gorler Klaus
Halbach Gunter
Schmidt Karlheinz
Soicke Hartwig
Madaus Aktiengesellschaft
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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