Flavonoids for treatment of diabetes

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/352 (2006.01) A61P 3/10 (2006.01) A61P 37/00 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2461563

Flavonoids, especially luteolin, are shown to be effective against insulin dependent (Type I) and insulin independent (Type II) diabetes mellitus. It is demonstrated that luteolin works in mammals by binding and blocking the Kv1.3 potassium channel of T-cell and Beta cells. Antidiabetic and anti-autoimmune compounds can be selected by measuring their ability to bind to and block the Kv1.3 channel.

L'invention démontre que les flavonoïdes, notamment la lutéoline, sont efficaces contre le diabète insulino-dépendant (Type I) et le diabète insulino-indépendant (Type II). Il est démontré que, chez les mammifères, la lutéoline fonctionne par liaison et blocage le canal potassique K¿v?1.3 des lymphocytes T et des cellules bêta. On peut choisir des composés antidiabétiques et anti-autoimmunes en mesurant leur capacité à se lier au canal potassique et à bloquer ce dernier.

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