Flavoring systems for pharmaceutical compositions and...

A - Human Necessities – 61 – K

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Details

A61K 31/425 (2006.01) A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 31/426 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61K 38/55 (2006.01)

Patent

CA 2417258

A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.

L'invention concerne un système d'aromatisation pour une composition pharmaceutique liquides, ainsi que des compositions pharmaceutiques contenant de tels systèmes d'aromatisation. Les systèmes d'aromatisation de cette invention comprennent au moins un édulcorant, au moins deux ingrédients aromatisés, et au moins un modificateur d'arôme choisi dans le groupe comprenant acide citrique, citrate de sodium, chlorure de sodium et des mélanges de ceux-ci. Au moins deux des ingrédients aromatisés sont choisis dans le groupe comprenant un ingrédient aromatisé à la vanille, un ingrédient aromatisé à la menthe poivrée, un ingrédient aromatisé au menthol, un ingrédient aromatisé à la barbe à papa, et des mélanges de ceux-ci. Le ou les édulcorants comprennent de la glycérine, du glycyrrhizinate monoammonique, du sodium de saccharine, de l'acésulfame-potassium, du sirop de glucose à haute teneur en fructose, et/ou des mélanges de ceux-ci. Les compositions pharmaceutiques de cette invention comprennent un système d'aromatisation de l'invention, un système de solvant, et au moins un agent actif du point de vue pharmaceutique, tel que du lopinavir ou des dérivés de celui-ci, du ritonavir ou des dérivés de celui-ci, ou des mélanges de ceux-ci. L'invention concerne également des procédés de fabrication de telles compositions pharmaceutiques liquides.

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