C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 38/55 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 7/01 (2006.01) C12N 9/48 (2006.01) C12N 9/50 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) A61K 35/00 (2006.01)
Patent
CA 2252581
The present invention relates to flea serine protease proteins and flea cysteine protease proteins; to flea serine protease and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
Protéines de sérine protéase de puces et protéines de cystéine protéase de puces, molécules d'acides nucléiques de sérine protéase et de cystéine protéase de puces, y compris celles qui codent lesdites protéines, anticorps contre lesdites protéines et composés qui inhibent l'activité de la sérine protéase et/ou de la cystéine protéase de puces. La présente invention comporte également des procédés permettant d'obtenir lesdites protéines, des molécules d'acides nucléiques, des anticorps et/ou des inhibiteurs, ainsi que l'utilisation desdites compositions thérapeutiques pour protéger un animal hôte de l'infestation par les puces.
Frank Glenn R.
Gaines Patrick J.
Grieve Robert B.
Hunter Shirley Wu
Rushlow Keith E.
Heska Corporation
Johnson Ernest Peter
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