C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/71 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12N 15/54 (2006.01) C12N 15/86 (2006.01) A61K 9/127 (2006.01)
Patent
CA 2149298
The present invention relates to the use of ligands for the Flk-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention is based, in part, on the demonstration that Flk- 1 tyrosine kinase receptor expression is associated with endothelial cells and the identification of vascular endothelial growth factor ("VEGF) as the high affinity ligand of Flk-1. These results indicate a major role for Flk-1 in the signaling system during vasculogenesis and angiogenesis. Engineering of host cells that express Flk-1 and the uses of expressed Flk-1 to evaluate and screen for drugs and analogs of VEGF involved in Flk-1 modulation by either agonist or antagonist activities is described. The invention also relates to the use of FLK-1 ligands, including VEGF agonists and antagonists. in the treatment of disorders, including cancer, by modulating vasculogenesis and angiogenesis.
Millauer Birgit
Risau Werner
Ullrich Axel
Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.v.
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.v.
Osler Hoskin & Harcourt Llp
LandOfFree
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