Flt3-l mutants and methods of use

Details Flt3-l mutants and methods of use Flt3-l mutants and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) C12N 5/071 (2010.01) C12N 5/0789 (2010.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61K 39/39 (2006.01) C07K 14/52 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2332345

A screening method for identifying mutant polypeptides having at least one amino acid difference from a wild type protein involved in a receptor-ligand interaction is disclosed. Also disclosed are mutant polypeptides of the hematopoietic growth factor flt3-Ligand (flt3-L) identified using this method, nucleic acids encoding these flt3-L mutant polypeptides, and methods of treatment involving in vitro and in vivo use of the mutant polypeptides and nucleic acids.

L'invention concerne une technique de criblage qui permet d'identifier des polypeptides mutants présentant au moins une différence d'acide aminé par rapport à une protéine de type sauvage impliquée dans une interaction récepteur-ligand; des polypeptides mutants du ligand du facteur de croissance hématopoïétique flt3 (flt3-L) identifiés par ladite technique; des acides nucléiques codant pour ces polypeptides mutants flt3; et des méthodes de traitement impliquant l'utilisation in vitro et in vivo desdits polypeptides et acides nucléiques mutants.

Affiliated with

Also associated with

Rating

Flt3-l mutants and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Flt3-l mutants and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Flt3-l mutants and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1663873