Flunisolide to treat respiratory diseases

Details Flunisolide to treat respiratory diseases Flunisolide to treat respiratory diseases

C - Chemistry, Metallurgy

07

J

260/15

C07J 71/00 (2006.01) A61K 9/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 1075228

Abstract Of The Disclosure Flunisolide, 6.alpha.-fluoro-11.beta.,21-dihydroxy-16.alpha.,17.alpha.-isopropyli- denedioxypregaa-1,4-diene-3,20-dione, is administered by inhala- tion in a therapeutically effective dosage to a person having a respiratory disease such as bronchial asthma and allergic rhinitis. A unique crystalline polymorphic form of flunisolide is prepared by contacting one of the other polymorphic forms of solid flunisolide with a suitable liquid in which flunisolide has substantially no solubility, especially Freon? 12 or Freon? 114 or by recrystallizing the unique crystalline form from a suitable solvent such as methylene chloride. The unique crystalline form is stable in aerosols such as Freon? mixtures and is valuable in the treatment of respiratory diseases.

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